Contribution of early-life unpredictability to neuropsychiatric symptom patterns in adulthood.

ABSTRACT:

Background

Recent studies in both human and experimental animals have identified fragmented and unpredictable parental and environmental signals as a novel source of early-life adversity. Early-life unpredictability may be a fundamental developmental factor that impacts brain development, including reward and emotional memory circuits, affecting the risk for psychopathology later in life. Here, we tested the hypothesis that self-reported early-life unpredictability is associated with psychiatric symptoms in adult clinical populations.

Methods

Using the newly validated Questionnaire of Unpredictability in Childhood, we assessed early-life unpredictability in 156 trauma-exposed adults, of which 65% sought treatment for mood, anxiety, and/or posttraumatic stress disorder (PTSD)

SUBMITTER: Spadoni AD 

PROVIDER: S-EPMC9881456 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature