Ontology highlight
ABSTRACT:
SUBMITTER: Yildirim Z
PROVIDER: S-EPMC9881502 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Yildirim Zehra Z Kojic Ana A Yan Christopher D CD Wu Matthew A MA Vagelos Randall R Wu Joseph C JC
Stem cell research 20221019
Dilated cardiomyopathy (DCM) is a progressive heart muscle disease that can culminate with heart failure and death. Mutations in several genes can cause DCM, including hyperpolarization-activated cyclic nucleotide-gated channel (HCN4), which has a critical function in the autonomic control of the heart rate. Here, we generated two human induced pluripotent stem cell (iPSC) lines generated from two DCM patients carrying variants in the HCN4 gene (c.2587G > T and c.2846G > A). Both lines display n ...[more]