Combined radical and ionic approach for the enantioselective synthesis of β-functionalized amines from alcohols.

ABSTRACT: Chiral amines are among the most important organic compounds and have widespread applications. Enantioselective construction of chiral amines is a major aim in organic synthesis. Among synthetic methods, direct functionalization of omnipresent C-H bonds with common organic nitrogen compounds represents one of the most attractive strategies. However, C-H amination strategies are largely limited to constructing a specific type of N-heterocycles or amine derivatives. To maximize the synthetic potential of asymmetric C-H amination, we report here an approach that unites the complementary reactivities of radical and ionic chemistry for streamlined synthesis of functionalized chiral amines. This synthesis merges the development of an enantioselective radical process for 1,5-C(sp

SUBMITTER: Lang K 

PROVIDER: S-EPMC9881596 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature