The Vasculature in Pulmonary Fibrosis.

ABSTRACT:

Purpose of review

The current paradigm of idiopathic pulmonary fibrosis (IPF) pathogenesis involves recurrent injury to a sensitive alveolar epithelium followed by impaired repair responses marked by fibroblast activation and deposition of extracellular matrix. Multiple cell types are involved in this response with potential roles suggested by advances in single-cell RNA sequencing and lung developmental biology. Notably, recent work has better characterized the cell types present in the pulmonary endothelium and identified vascular changes in patients with IPF.

Recent findings

Lung tissue from patients with IPF has been examined at single-cell resolution, revealing reductions in lung capillary cells and expansion of a population of vascular cells expressing markers associat

SUBMITTER: Engelbrecht E 

PROVIDER: S-EPMC9881604 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature