Hemocompatibility of all-trans retinoic acid-loaded citrate polymer coatings for vascular stents.

ABSTRACT:

Purpose

Current strategies implementing drug-eluting polymer stent coatings fail to fully address the lasting effects of endothelial suppression which ultimately result in delayed reendothelialization and thrombogenic complications. The present study investigates the in vitro hemocompatibility of all-trans retinoic acid loaded poly (1,8-octanediol-co-citrate) coatings (AtRA-POC coatings) for advanced intravascular stent technology. The ability of these materials in supporting endothelial restoration via migration and proliferation while inhibiting smooth muscle cell growth is also explored.

Methods

Using in vitro models, the hemocompatibility of AtRA-loaded POC-coated cobalt chromium (CoCr) vascular stents was evaluated in terms of platelet and inflammatory activity.

SUBMITTER: Ursino H 

PROVIDER: S-EPMC9881644 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature