Evolution of antigen-specific follicular helper T cell transcription from effector function to memory.

ABSTRACT: Understanding how follicular helper T cells (TFH) regulate the specialization, maturation, and differentiation of adaptive B cell immunity is crucial for developing durable high-affinity immune protection. Using indexed single-cell molecular strategies, we reveal a skewed intraclonal assortment of higher-affinity T cell receptors and the distinct molecular programming of the localized TFH compartment compared with emigrant conventional effector T_H cells. We find a temporal shift in B cell receptor class switch, which permits identification of inflammatory and anti-inflammatory modules of transcriptional programming that subspecialize TFH function before and during the germinal center (GC) reaction. Late collapse of this local primary GC reaction reveals a persistent post-GC TFH

SUBMITTER: Robinson AM 

PROVIDER: S-EPMC9881730 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature