Not all clusters are equal: dynamics of molecular HIV-1 clusters in a statewide Rhode Island epidemic.

ABSTRACT:

Objectives

Molecular epidemiology is a powerful tool to characterize HIV epidemics and prioritize public health interventions. Typically, HIV clusters are assumed to have uniform patterns over time. We hypothesized that assessment of cluster evolution would reveal distinct cluster behavior, possibly improving molecular epidemic characterization, towards disrupting HIV transmission.

Design

Retrospective cohort.

Methods

Annual phylogenies were inferred by cumulative aggregation of all available HIV-1 pol sequences of individuals with HIV-1 in Rhode Island (RI) between 1990 and 2020, representing a statewide epidemic. Molecular clusters were detected in annual phylogenies by strict and relaxed cluster definition criteria, and the impact of annual newly-diagnosed HIV-1 ca

SUBMITTER: Novitsky V 

PROVIDER: S-EPMC9881752 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature