Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland.

ABSTRACT: Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at residue 226 of the prion protein. Here we performed transmissions in gene-targeted mice to investigate the properties of prions causing newly emergent CWD in moose in Finland. Although CWD prions from Finland and Norway moose had comparable responses to primary structural differences at residue 226, other distinctive criteria, including transmission kinetics, patterns of neuronal degeneration, and conformational features of prions generated in the brains of diseased mice, demonstrated that the strain properties of Finland moose CWD prions are

SUBMITTER: Sun JL 

PROVIDER: S-EPMC9881765 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature