Advanced HIV disease and engagement in care among patients on antiretroviral therapy in South Africa: results from a multi-state model.

ABSTRACT:

Objective

Despite improved access to antiretroviral therapy (ART) for people with HIV (PWH), HIV continues to contribute considerably to morbidity and mortality. Increasingly, advanced HIV disease (AHD) is found among PWH who are ART-experienced.

Design

Using a multi-state model we examined associations between engagement with care and AHD on ART in South Africa.

Methods

Using data from IeDEA Southern Africa, we included PWH from South Africa, initiating ART from 2004 to 2017 aged more than 5 years with a CD4+ cell count at ART start and at least one subsequent measure. We defined a gap as no visit for at least 18 months. Five states were defined: 'AHD on ART' (CD4+ cell count <200 cells/μl), 'Clinically Stable on ART' (CD4+ cell count ≥200 or if no CD4+ cell count, v

SUBMITTER: Patten GE 

PROVIDER: S-EPMC9881824 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature