MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.

ABSTRACT: The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alter expression of molecular clock genes, leading to a disruption of molecular clock oscillation across cancer types. It remains unclear what benefit cancer cells gain from suppressing clock oscillation, and how this loss of molecular clock oscillation impacts global gene expression and metabolism in cancer. We hypothesized that MYC or its paralog N-MYC (collectively termed MYC herein) suppress oscillation of gene expression and metabolism to upregulate pathways involved in biosynthesis in a static, non-oscillatory fashion. To test this, cells from distinct

SUBMITTER: Cazarin J 

PROVIDER: S-EPMC9881876 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature