A bioinformatics screen reveals Hox and chromatin remodeling factors at the Drosophila histone locus.

ABSTRACT: Cells orchestrate histone biogenesis with strict temporal and quantitative control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered at a single locus. Regulatory factors concentrate in a nuclear body known as the histone locus body (HLB), which forms around the locus. Historically, HLB factors are largely discovered by chance, and few are known to interact directly with DNA. It is therefore unclear how the histone genes are specifically targeted for unique and coordinated regulation. To expand the list of known HLB factors, we performed a candidate-based screen by mapping 30 publicly available ChIP datasets and 27 factors to the Drosophila histone gene array. We identified novel t

SUBMITTER: Hodkinson LJ 

PROVIDER: S-EPMC9881919 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature