APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia.

ABSTRACT:

Rationale

Acute intermittent hypoxia (AIH) is a promising strategy to induce functional motor recovery following chronic spinal cord injuries and neurodegenerative diseases. Although significant results are obtained, human AIH trials report considerable inter-individual response variability.

Objectives

Identify individual factors ( e.g. , genetics, age, and sex) that determine response magnitude of healthy adults to an optimized AIH protocol, acute intermittent hypercapnic-hypoxia (AIHH).

Methods

Associations of individual factors with the magnitude of AIHH (15, 1-min O ₂ =9.5%, CO ₂ =5% episodes) induced changes in diaphragm motor-evoked potential amplitude (MEP) and inspiratory mouth occlusion pressures (P _0.1 ) were evaluated

SUBMITTER: Nair J 

PROVIDER: S-EPMC9881941 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature