Hypersensitivity to distractors in Fragile X syndrome from loss of modulation of cortical VIP interneurons.

ABSTRACT: Attention deficit is one of the most prominent and disabling symptoms in Fragile X Syndrome (FXS). Hypersensitivity to sensory stimuli contributes to attention difficulties by overwhelming and/or distracting affected individuals, which disrupts activities of daily living at home and learning at school. We find that auditory or visual distractors selectively impair visual discrimination performance in both humans and mice with FXS, but not their typically developing controls. Vasoactive intestinal polypeptide (VIP) neurons were significantly modulated by incorrect responses in the post-stimulus period during early distractor trials in WT mice, consistent with their known role as 'error' signals. Strikingly, however, VIP cells from Fmr1^-/- mice showed little modulation in e

SUBMITTER: Rahmatullah N 

PROVIDER: S-EPMC9881942 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature