Functional Topography of the Neocortex Predicts Covariation in Complex Cognitive and Basic Motor Abilities.

ABSTRACT: Although higher-order cognitive and lower-order sensorimotor abilities are generally regarded as distinct and studied separately, there is evidence that they not only covary but also that this covariation increases across the lifespan. This pattern has been leveraged in clinical settings where a simple assessment of sensory or motor ability (e.g., hearing, gait speed) can forecast age-related cognitive decline and risk for dementia. However, the brain mechanisms underlying cognitive, sensory, and motor covariation are largely unknown. Here, we examined whether such covariation in midlife reflects variability in common versus distinct neocortical networks using individualized maps of functional topography derived from BOLD fMRI data collected in 769 45-year old members of a population-repre

SUBMITTER: Whitman ET 

PROVIDER: S-EPMC9881949 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature