Functional connectivity favors aberrant visual network c-Fos expression accompanied by cortical synapse loss in amyloidosis.

ABSTRACT: While Alzheimer's disease (AD) has been extensively studied with a focus on cognitive networks, sensory network dysfunction has received comparatively less attention despite compelling evidence of its significance in both Alzheimer's disease patients and mouse models. We recently found that neurons in the primary visual cortex of an amyloid mouse model exhibit an imbalance of postsynaptic structures favoring neuronal hyperactivity alongside increased c-Fos expression, which regulates plasticity and memory. Here, we investigate aberrant visual network and brain-wide c-Fos expression and functional connectivity patterns, network responses to light deprivation, and visual system presynaptic deficits of a mouse model of Alzheimer's disease. We found that the mouse model of AD exhibits aberrant

SUBMITTER: L'Esperance OJ 

PROVIDER: S-EPMC9881957 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature