Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns.

ABSTRACT: Staphylococcus epidermidis and S. aureus are highly problematic bacteria in hospital settings. This stems, at least in part, from strong abilities to form biofilms on abiotic or biotic surfaces. Biofilms are well-organized multicellular aggregates of bacteria, which, when formed on indwelling medical devices, lead to infections that are difficult to treat. Cell wall-anchored (CWA) proteins are known to be important players in biofilm formation and infection. Many of these proteins have putative stalk-like regions or regions of low complexity near the cell wall-anchoring motif. Recent work demonstrated the strong propensity of the stalk region of the S. epidermidis accumulation-associated protein (Aap) to remain highly extended under solution conditions that typically i

SUBMITTER: Yarawsky AE 

PROVIDER: S-EPMC9881980 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature