Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.

ABSTRACT: Ion channels play critical roles in the physiology and function of the nervous system and contractile tissue; however, their role in non-contractile tissue and embryonic development has yet to be understood. Tracheobronchomalacia (TBM) and complete tracheal rings (CTR) are disorders affecting the muscle and cartilage of the trachea and bronchi, whose etiology remains poorly understood. We demonstrated that trachealis muscle organization and polarity are disrupted after epithelial ablation of Wls, a cargo receptor critical for the Wnt signaling pathway, in developing trachea. The phenotype resembles the anomalous trachealis muscle observed after deletion of ion channel encoding genes in developing mouse trachea. We sought to investigate whether and how the deletion of Wls affects ion

SUBMITTER: Russell NX 

PROVIDER: S-EPMC9882072 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature