Candida albicans oropharyngeal infection is an exception to iron-based nutritional immunity.

ABSTRACT: Candida albicans is a commensal of the human gastrointestinal tract and one of the most causes of human fungal disease, including mucosal infections such as oropharyngeal candidiasis and disseminated infections of the bloodstream and deep organs. We directly compared the in vivo transcriptional profile of C. albicans during oral infection and disseminated infection of the kidney to identify niche specific features. Although the expression of a set of environmentally responsive genes were correlated in the two infection sites (Pearson R ² , 0.6), XXX genes were differentially expressed. Virulence associated genes such as hyphae-specific transcripts were expressed similarly in the two sites. Genes expressed during growth in a poor carbon source ( ACS1 and P

SUBMITTER: Solis NV 

PROVIDER: S-EPMC9882133 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature