Insulin-mediated endothelin signaling is antiviral during West Nile virus infection.

ABSTRACT: West Nile virus (WNV) is the most prevalent mosquito-borne virus in the United States with approximately 2,000 cases each year. There are currently no approved human vaccines and a lack of prophylactic and therapeutic treatments. Understanding host responses to infection may reveal potential intervention targets to reduce virus replication and disease progression. The use of Drosophila melanogaster as a model organism to understand innate immunity and host antiviral responses is well established. Previous studies revealed that insulin-mediated signaling regulates WNV infection in invertebrates by regulating canonical antiviral pathways. Because insulin signaling is well-conserved across insect and mammalian species, we sought to determine if results using D. melanogaster can

SUBMITTER: Trammell CE 

PROVIDER: S-EPMC9882177 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature