Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine.

ABSTRACT: Drugs of abuse increase extracellular concentrations of dopamine in the nucleus accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and behavioral adaptations. While decades of research have focused on the transcriptional mechanisms by which drugs of abuse influence neuronal physiology and function, few studies have comprehensively defined NAc cell type heterogeneity in transcriptional responses to drugs of abuse. Here, we used single nucleus RNA-seq (snRNA-seq) to characterize the transcriptome of over 39,000 NAc cells from male and female adult Sprague-Dawley rats following acute or repeated cocaine experience. This dataset identified 16 transcriptionally distinct cell populations, including two populations of medium spiny neurons (MSNs) that expres

SUBMITTER: Phillips RA 

PROVIDER: S-EPMC9882178 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature