High-throughput sequencing of macaque basolateral amygdala projections reveals dissociable connectional motifs with frontal cortex.

ABSTRACT: The basolateral amygdala (BLA) projects widely across the macaque frontal cortex^1-4, and amygdalo-frontal projections are critical for optimal emotional responding⁵ and decision-making⁶. Yet, little is known about the single-neuron architecture of these projections: namely, whether single BLA neurons project to multiple parts of the frontal cortex. Here, we use MAPseq⁷ to determine the projection patterns of over 3000 macaque BLA neurons. We found that one-third of BLA neurons have two or more distinct targets in parts of frontal cortex and of subcortical structures. Further, we reveal non-random structure within these branching patterns such that neurons with four targets are more frequently observed than those with two or three, indicative of w

SUBMITTER: Zeisler ZR 

PROVIDER: S-EPMC9882200 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature