Normative modeling of brain morphometry in Clinical High-Risk for Psychosis.

ABSTRACT:

Importance

The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in the majority of individuals at psychosis risk may be nested within the range observed in healthy individuals.

Objective

To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high-risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder.

Design setting and participants

Clinical, IQ and FreeSurfer-derived regional measures of cortical thickness (CT), cortical surface area (SA), and subcortical volume (SV) from

SUBMITTER: Haas SS 

PROVIDER: S-EPMC9882206 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature