Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen.

ABSTRACT: Animals have evolved two defense strategies to survive infections. Antagonistic strategies include mechanisms of immune resistance that operate to sense and kill invading pathogens. Cooperative or physiological defenses mediate host adaptation to the infected state, limiting physiological damage and disease, without killing the pathogen, and have been shown to cause asymptomatic carriage and transmission of lethal pathogens. Here we demonstrate that physiological defenses cooperate with the adaptive immune response to generate long-term asymptomatic carriage of the lethal enteric murine pathogen, Citrobacter rodentium. Asymptomatic carriage of genetically virulent C. rodentium provided immune resistance against subsequent infections. Host immune protection was dependent on systemic antibod

SUBMITTER: Chen GY 

PROVIDER: S-EPMC9882269 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature