Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.

ABSTRACT: Prematurity is among the leading risks for poor neurocognitive outcomes. The brains of preterm infants show alterations in structure and electrical activity, but the underlying circuit mechanisms are unclear. To address this, we performed a cross-species study of the electrophysiological activity in the visual cortices of prematurely born infants and mice. Using electroencephalography (EEG) in a sample of healthy preterm (N=29) and term (N=28) infants, we found that the maturation of the aperiodic EEG component was accelerated in the preterm cohort, with a significantly flatter 1/f slope when compared to the term infants. The flatter slope was a result of decreased spectral power in the theta and alpha bands and was correlated with the degree of prematurity. To determine the circuit and ce

SUBMITTER: Witteveen IF 

PROVIDER: S-EPMC9882279 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature