Modeling of African population history using f -statistics can be highly biased and is not addressed by previously suggested SNP ascertainment schemes.

ABSTRACT: f -statistics have emerged as a first line of analysis for making inferences about demographic history from genome-wide data. These statistics can provide strong evidence for either admixture or cladality, which can be robust to substantial rates of errors or missing data. f -statistics are guaranteed to be unbiased under "SNP ascertainment" (analyzing non-randomly chosen subsets of single nucleotide polymorphisms) only if it relies on a population that is an outgroup for all groups analyzed. However, ascertainment on a true outgroup that is not co-analyzed with other populations is often impractical and uncommon in the literature. In this study focused on practical rather than theoretical aspects of SNP ascertainment, we show that many non-outgroup ascertainment schemes lead

SUBMITTER: Flegontov P 

PROVIDER: S-EPMC9882349 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature