Mechanistic Basis for Enhanced Strigolactone Sensitivity in KAI2 Triple Mutant.

ABSTRACT: Striga hermonthica is a parasitic weed that destroys billions of dollars' worth of staple crops every year. Its rapid proliferation stems from an enhanced ability to metabolize strigolactones (SLs), plant hormones that direct root branching and shoot growth. Striga's SL receptor, ShHTL7, bears more similarity to the staple crop karrikin receptor KAI2 than to SL receptor D14, though KAI2 variants in plants like Arabidopsis thaliana show minimal SL sensitivity. Recently, studies have indicated that a small number of point mutations to HTL7 residues can confer SL sensitivity to AtKAI2. Here, we analyze both wild-type AtKAI2 and SL-sensitive mutant Var64 through all-atom, long-timescale molecular dynamics simulations to determine the effects of these m

SUBMITTER: Sobecks BL 

PROVIDER: S-EPMC9882355 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature