The impact of early life experiences and gut microbiota on neurobehavioral development among preterm infants: A longitudinal cohort study.

ABSTRACT:

Objectives

To investigate the impact of early life experiences and gut microbiota on neurobehavioral development among preterm infants during neonatal intensive care unit (NICU) hospitalization.

Methods

Preterm infants were followed from the NICU admission until their 28 ^th postnatal day or until discharge. Daily stool samples, painful/stressful experiences, feeding patterns, and other clinical and demographic data were collected. Gut microbiota was profiled using 16S rRNA sequencing, and operational taxonomic units (OTUs) were selected to predict the neurobehaviors. The neurobehavioral development was assessed by the Neonatal Neurobehavioral Scale (NNNS) at 36 to 38 weeks of post-menstrual age (PMA). Fifty-five infants who had NNNS measurements were included in t

SUBMITTER: Chen J 

PROVIDER: S-EPMC9882379 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature