Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.

ABSTRACT:

Background

Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand the characteristic immunopathology of tuberculosis. We performed targeted metabolomic analyses in a large cohort of patients with tuberculous meningitis (TBM), the most severe manifestation of tuberculosis, focusing on tryptophan metabolism.

Methods

We studied 1069 Indonesian and Vietnamese adults with TBM (26.6% HIV-positive), 54 non-infectious controls, 50 with bacterial meningitis, and 60 with cryptococcal meningitis. Tryptophan and downstream metabolites were measured in cerebrospinal fluid (CSF) and plasma using targeted liquid chromatography mass-spectrometry. Individual metabolite levels were associated with survival, clinical paramet

SUBMITTER: Ardiansyah E 

PROVIDER: S-EPMC9882445 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature