Structure of an endogenous mycobacterial MCE lipid transporter.

ABSTRACT: To replicate inside human macrophages and cause the disease tuberculosis, Mycobacterium tuberculosis ( Mtb ) must scavenge a variety of nutrients from the host ^1,2 . The Mammalian Cell Entry (MCE) proteins are important virulence factors in Mtb ^1,3 , where they are encoded in large gene clusters and have been implicated in the transport of fatty acids ^4â€"7 and cholesterol ^1,4,8 across the impermeable mycobacterial cell envelope. Very little is known about how cargos are transported across this barrier, and how the ~10 proteins encoded in a mycobacterial mce gene cluster might assemble to transport cargo

SUBMITTER: Chen J 

PROVIDER: S-EPMC9882608 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature