Immune response to the mRNA COVID-19 vaccine in hemodialysis patients: cohort study.

ABSTRACT:

Background

End-stage renal disease (ESRD) patients experience immune compromise characterized by complex alterations of both innate and adaptive immunity, and results in higher susceptibility to infection and lower response to vaccination. This immune compromise, coupled with greater risk of exposure to infectious disease at hemodialysis (HD) centers, underscores the need for examination of the immune response to the COVID-19 mRNA-based vaccines.

Methods

A transcriptomic analysis of the immune response to the Covid-19 BNT162b2 mRNA vaccine was assessed in 20 HD patients and cohort-matched controls. RNA sequencing of peripheral blood mononuclear cells (PBMCs) was performed longitudinally before and after each vaccination dose for a total of six time points per subject. Anti-s

SUBMITTER: Chang YS 

PROVIDER: S-EPMC9882629 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature