Identity by descent mapping of HCV spontaneous clearance in populations of diverse ancestry.

ABSTRACT: Background Acute infection with hepatitis C virus (HCV) affects millions of individuals worldwide. Host genetics plays a role in spontaneous clearance of the acute infection which occurs in approximately 30% of the individuals. Common variants in GPR158 , genes in the interferon lambda ( IFNL) cluster, and the MHC region have been associated with HCV clearance in populations of diverse ancestry. Fine mapping of those regions has identified some key variants and amino acids as potential causal variants but the role of rare variants in those regions and in the genome, in general, has not been explored. We aimed to detect haplotypes containing rare variants related to HCV clearance using identity-by-descent (IBD) haplotype sharing between unrelated cases/case pairs and case/cont

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9882640 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature