Association Between Genetically Predicted Expression of TPMT and Azathioprine Adverse Events.

ABSTRACT: Polymorphisms thiopurine-S-methyltransferase ( TPMT ) and nudix hydrolase 15 ( NUDT15 ) can increase the risk of azathioprine myelotoxicity, but little is known about other genetic factors that increase risk for azathioprine-associated side effects. PrediXcan is a gene-based association method that estimates the expression of individuals’ genes and examines their correlation to specified phenotypes. As proof of concept for using PrediXcan as a tool to define the association between genetic factors and azathioprine side effects, we aimed to determine whether the genetically predicted expression of TPMT or NUDT15 was associated with leukopenia or other known side effects. In a retrospective cohort of 1364 new users of azathioprine with EHR-reported White race, we used PrediXc

SUBMITTER: Davis A 

PROVIDER: S-EPMC9882694 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature