Contribution of remote M.tuberculosis infection to tuberculosis disease: A 30-year population study.

ABSTRACT:

Background

The importance of remote infection with M.tuberculosis as a cause of tuberculosis disease (TB) is unclear, with limited evidence of impact on TB rates beyond 10 years. Our objective was to assess rates of tuberculosis over 30 years by M.tuberculosis infection status at baseline in Karonga District, Northern Malawi.

Materials and methods

Population-based surveys of tuberculin skin testing (TST) from the 1980s were linked with follow-up and TB surveillance in Karonga district. We compared rates of microbiologically-confirmed TB by baseline TST induration <5mm (no evidence of M.tuberculosis infection) and those with baseline TST >17mm (evidence of M.tuberculosis infection), using hazard ratios by time since baseline and attributable risk percent. The attributable ris

SUBMITTER: Glynn JR 

PROVIDER: S-EPMC9882759 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature