Association of tumor-infiltrating lymphocytes with survival depends on primary tumor sidedness in stage III colon cancers (NCCTG N0147) [Alliance].

ABSTRACT:

Background

Tumor-infiltrating lymphocytes (TILs) are a robust and independent prognostic variable in localized colon cancer. Given reported differences in molecular features and prognosis of right- versus left-sided tumors, we examined the association of TIL densities with patient survival by primary tumor sidedness in stage III cancers, including clinical low- (T_1-3, N₁) and high-risk (T₄ and/or N₂) groups.

Patients and methods

In a phase III trial of FOLFOX-based adjuvant chemotherapy, TIL densities were analyzed and dichotomized in colon carcinomas (N = 1532) based on a previously determined cut point optimized for disease-free survival (DFS). Right-sided tumors were defined as proximal to the splenic flexure. Associations of TI

SUBMITTER: Saberzadeh-Ardestani B 

PROVIDER: S-EPMC9882989 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature