Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a leading cause of blindness in the industrialised world and is projected to affect >280 million people worldwide by 2040. Aiming to identify causal factors and potential therapeutic targets for this common condition, we designed and undertook a phenome-wide Mendelian randomisation (MR) study.

Methods

We evaluated the effect of 4591 exposure traits on early AMD using univariable MR. Statistically significant results were explored further using: validation in an advanced AMD cohort; MR Bayesian model averaging (MR-BMA); and multivariable MR.

Results

Overall, 44 traits were found to be putatively causal for early AMD in univariable analysis. Serum proteins that were found to have significant relationships with AMD inc

SUBMITTER: Julian TH 

PROVIDER: S-EPMC9883012 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature