Alterations in platelet proteome signature and impaired platelet integrin α_IIbβ₃ activation in patients with COVID-19.

ABSTRACT:

Background

Patients with COVID-19 are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality.

Objectives

To characterize the mechanism of altered platelet function in COVID-19 patients.

Methods

The platelet proteome, platelet functional responses, and platelet-neutrophil aggregates were compared between patients hospitalized with COVID-19 and healthy control subjects using tandem mass tag proteomic analysis, Western blotting, and flow cytometry.

Results

COVID-19 patients showed a different profile of platelet protein expression (858 altered of the 5773 quantified). Levels of COVID-19 plasma markers were enhanced in the platelets of COVID-19 patients. Gene ontology pathway analysis d

SUBMITTER: Goudswaard LJ 

PROVIDER: S-EPMC9883069 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature