School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study.

ABSTRACT:

Background

Poor school performance is linked to higher risks of self-harm. The association might be explained through genetic liabilities for depression or educational attainment. We investigated the association between school performance and self-harm in a population-based sample while assessing the potential influence of polygenic risk scores (PRSs) for depression (PRS_MDD) and for educational attainment (PRS_EDU).

Method

We conducted a follow-up study of individuals born 1987-98 and followed from age 18 until 2016. The total sample consisted of a case group (23,779 diagnosed with mental disorders; schizophrenia, bipolar disorder, depression, autism, and attention deficit hyperactivity disorder (ADHD) and a randomly sampled comparison group (n = 

SUBMITTER: Sorensen HJ 

PROVIDER: S-EPMC9883111 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature