Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia.

ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by mutations in genes encoding transcriptional and epigenetic regulators together with signaling genes. It is characterized by a disturbance of differentiation and abnormal proliferation of hematopoietic progenitors. We have previously shown that each AML subtype establishes its own core gene regulatory network (GRN), consisting of transcription factors binding to their target genes and imposing a specific gene expression pattern that is required for AML maintenance. In this study, we integrate gene expression, open chromatin and ChIP data with promoter-capture Hi-C data to define a refined core GRN common to all patients with CEBPA-double mutant (CEBPA^N/C) AML. These mutations disrupt the structure

SUBMITTER: Adamo A 

PROVIDER: S-EPMC9883165 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature