Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.

ABSTRACT: The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory and signaling levels. Recently, a long-tail hotspot mutation targeting the R-RAS2/TC21 Gln⁷² residue (Q72L) was identified as a potent oncogenic driver. Additional point mutations were also found in other tumors at low frequencies. Despite this, little information is available regarding the transforming role of these mutant versions and their relevance for the tumorigenic properties of already-transformed cancer cells. Here, we report that many of the RRAS2 mutations found in human cancers are highly transforming when expressed in immortalized cell lines. Moreover, the expression of endogenous R-RAS2^Q72L is important for ma

SUBMITTER: Clavain L 

PROVIDER: S-EPMC9883167 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature