MHCII expression on gut macrophages supports T cell homeostasis and is regulated by microbiota and ontogeny.

ABSTRACT: Macrophages are traditionally considered antigen-presenting cells. However, their ability to present antigen and the factors regulating macrophage MHCII expression are poorly understood. Here, we demonstrate that MHCII expression on murine intestinal macrophages is differentially controlled by their residence in the small intestine (SI) or the colon, their ontogeny and the gut microbiota. Monocyte-derived macrophages are uniformly MHCII^hi, independently of the tissue of residence, microbial status or the age of the mouse, suggesting a common monocyte differentiation pathway. In contrast, MHCII expression on long-lived, prenatally-derived Tim4⁺ macrophages is low after birth but significantly increases at weaning in both SI and colon. Furthermore, MHCII expression on c

SUBMITTER: Guillaume J 

PROVIDER: S-EPMC9883227 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature