Effect of prior treatments on post-CDK 4/6 inhibitor survival in hormone receptor-positive breast cancer.

ABSTRACT:

Purpose

Multiple treatment options exist for patients with metastatic breast cancer (MBC). However, limited information is available on the impact of prior treatment duration and class on survival outcome for novel therapies, such as cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+ HER2-) MBC.

Methods

This study used a nationwide, de-identified electronic health record-derived database to identify women with HR+ HER2- MBC who received at least one CDK 4/6i between 2011 and 2020. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for the association between prior duration and class of cancer treatment (both early-stage and metastatic) and prior CDK 4/6i surviva

SUBMITTER: Franks J 

PROVIDER: S-EPMC9883320 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature