Assessing the role of tumour-associated macrophage subsets in breast cancer subtypes using digital image analysis.

ABSTRACT:

Purpose

The number of M1-like and M2-like tumour-associated macrophages (TAMs) and their ratio can play a role in breast cancer development and progression. Early clinical trials using macrophage targeting compounds are currently ongoing. However, the most optimal detection method of M1-like and M2-like macrophage subsets and their clinical relevance in breast cancer is still unclear. We aimed to optimize the assessment of TAM subsets in different breast cancer subtypes, and therefore related TAM subset numbers and ratio to clinicopathological characteristics and clinical outcome.

Methods

Tissue microarrays of 347 consecutive primary Luminal-A, Luminal-B, HER2-positive and triple-negative tumours of patients with early-stage breast cancer were serially sectioned and immunohi

SUBMITTER: Zwager MC 

PROVIDER: S-EPMC9883348 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature