Dopaminergic Dysfunction and Glucose Metabolism Characteristics in Parkin-Induced Early-Onset Parkinson's Disease Compared to Genetically Undetermined Early-Onset Parkinson's Disease.

ABSTRACT: While early-onset Parkinson's disease (EOPD) caused by mutations in the parkin gene (PRKN) tends to have a relatively benign course compared to genetically undetermined (GU)-EOPD, the exact underlying mechanisms remain elusive. We aimed to search for the differences between PRKN-EOPD and GU-EOPD by dopamine transporter (DAT) and glucose metabolism positron-emission-tomography (PET) imaging. Twelve patients with PRKN-EOPD and 16 with GU-EOPD who accepted both ¹¹C-2b-carbomethoxy-3b-(4-trimethylstannylphenyl) tropane (¹¹C-CFT) and ¹⁸F-fluorodeoxyglucose PET were enrolled. The ¹¹C-CFT uptake was analyzed on both regional and voxel levels, whereas glucose metabolism was assessed in a voxel-wise fashion. Correlations between DAT a

SUBMITTER: Liu FT 

PROVIDER: S-EPMC9883374 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature