Adjustment for the Age- and Gender-Related Metabolic Changes Improves the Differential Diagnosis of Parkinsonism.

ABSTRACT: Age and gender are the important factors for brain metabolic declines in both normal aging and neurodegeneration, and the confounding effects may influence early and differential diagnosis of neurodegenerative diseases based on the [¹⁸F]fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG PET). We aimed to explore the potential of the adjustment of age- and gender-related confounding factors on [¹⁸F]FDG PET images in differentiation of Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supra-nuclear palsy (PSP). Eight hundred and seventy-seven clinically definitely diagnosed Parkinsonian patients from a benchmark Huashan Parkinsonian PET imaging database were included. An age- and gender-adjusted Z (AGAZ) score was established base

SUBMITTER: Lu J 

PROVIDER: S-EPMC9883378 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature