Construction and validation of a nomogram based on N6-Methylandenosine-related lncRNAs for predicting the prognosis of non-small cell lung cancer patients.

ABSTRACT:

Background

The N6-methyladenosine (m⁶ A) can modify long non-coding RNAs (lncRNAs), thereby influencing a wide array of biological functions. However, the prognosis of m⁶ A-related lncRNAs (m⁶ ARLncRNAs) in non-small cell lung cancer (NSCLC) remains largely unknown.

Methods

Pearson correlation analysis was used to identify m⁶ ARLncRNAs in 1835 NSCLC patients and with the condition (|Pearson R| > 0.4 and p < 0.001). Univariant Cox regression analysis was conducted to explore the prognostic m⁶ ARLncRNAs. We filtered prognostic m⁶ ARLncRNAs by LASSO regression and multivariate Cox proportional hazard regression to construct and validate an m⁶ ARLncRNAs signature (m⁶ ARLncSig). We analyzed th

SUBMITTER: Xiao W 

PROVIDER: S-EPMC9883402 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature