Dataset Information

A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years.

ABSTRACT:

Background

The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors.

Methods

This retrospective single-center cohort study enrolled 68 patients with newly diagnosed unfavorable cancer of unknown primary at Taipei Veteran General Hospital from 2017 to 2020 as study cohort and 167 patients from 2000 to 2009 as historical cohort.

Results

The median overall survival was 4.3 months in the study cohort (95% CI, 2.7-6.2 months) and 4.5 months in the historical cohort (95% CI, 3.0-5.5 months; p = 0.858). Eleven patients in the study cohort received immunotherapy. The disease control rates were 45%. Multivariate analysis showed that an Eastern Cooperative Oncology Group score > 1 and a C-reactive protein level > 1 correlated with poor survival. A new prognostic stratification model was constructed by using Eastern Cooperative Oncology Group score and C-reactive protein values. The good-, intermediate-, and poor-risk groups had distinct median overall survival of 18.3, 7.0 and 1.2 months, respectively (area under the curve, 0.817; p < 0.001).

Conclusion

The outcome of unfavorable cancer of unknown primary has not changed much over the last 20 years. The application of a new prognostic stratification model can further stratify unfavorable cancer of unknown primary.

SUBMITTER: Tang CY

PROVIDER: S-EPMC9883408 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years.

Tang Cheng-Yu CY Hang Jen-Fan JF Hung Yi-Ping YP Chiu Nai-Chi NC Lai Jiun-I JI Chen Ming-Huang MH Liu Chun-Yu CY Yang Muh-Hwa MH Chao Yee Y Chang Peter Mu-Hsin PM

Cancer medicine 20220703 2

<h4>Background</h4>The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors.<h4>Methods</h4>This retrospective single-center cohort study enrolled 68 patients with newly diagnosed unfavorable cancer of unknown primary at Taipei Veteran General Hospital from 2017 to 2020 as study cohort and 167 patients from 2000 to 2009 as historical cohort.<h4>Results</h4>The me ...[more]

PMID: 35781808

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Dataset Information

A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years.

Background

Methods

Results

Conclusion

Publications

A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years.

Similar Datasets

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