A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years.

ABSTRACT:

Background

The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors.

Methods

This retrospective single-center cohort study enrolled 68 patients with newly diagnosed unfavorable cancer of unknown primary at Taipei Veteran General Hospital from 2017 to 2020 as study cohort and 167 patients from 2000 to 2009 as historical cohort.

Results

The median overall survival was 4.3 months in the study cohort (95% CI, 2.7-6.2 months) and 4.5 months in the historical cohort (95% CI, 3.0-5.5 months; p = 0.858). Eleven patients in the study cohort received immunotherapy. The disease control rates were 45%. Multivariate analysis showed that an Eastern

SUBMITTER: Tang CY 

PROVIDER: S-EPMC9883408 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature