BRD9 is an essential regulator of glycolysis that creates an epigenetic vulnerability in colon adenocarcinoma.

ABSTRACT:

Background

The intensive interplay between aberrant epigenetic events and metabolic remodeling represents one of the hallmarks of tumors, including colon cancer. The functions of Bromodomain Containing Protein BRD-9 in colon cancer remains indefinite. We aimed to identify the biological roles and clinical significance of BRD9 in colon cancer.

Methods

The univariate- and multi-variate Cox regression models were used to screen risk epigenetic regulators. Kaplan-Meier analysis and Pearson correlation analysis were used to assess clinical significance of BRD9. CCK-8 assays, colony formation assay, Transwell, and soft-agar assay were performed to determine the in vitro roles of BRD9. The oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of colon cancer cel

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC9883419 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature