A case-control study to evaluate the impact of the breast screening programme on breast cancer incidence in England.

ABSTRACT:

Background

There is uncertainty about overdiagnosis in mammography screening.

Methods

We aimed to estimate the effect of screening on breast cancer incidence and overdiagnosis in the NHS Breast Screening Programme in England. The study included 57,493 cases and 105,653 controls, with cases defined as women diagnosed at ages 47-89 with primary breast cancer, invasive or ductal carcinoma in situ, in 2010 or 2011. Where possible, two controls were selected per case, matched on date of birth and screening area. Conditional logistic regression was used to estimate the effect of screening on breast cancer risk, with adjustment for potential self-selection bias. Results were combined with national incidence data to estimate absolute rates of overdiagnosis. Overdiagnosis was calcula

SUBMITTER: Blyuss O 

PROVIDER: S-EPMC9883434 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature