EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma.

ABSTRACT:

Background

As a member of the Ephrin protein family that elicits short distance cell-cell signaling, EphrinA3 has been shown to promote or inhibit tumorigenesis depending on tumor types, but its roles and the underlying mechanisms in lung adenocarcinoma (LUAD) have not been reported.

Materials and methods

The TCGA database and Kaplan-Meier Plotter database were used to analyze the differential expression of EphrinA3 between LUAD and para-carcinoma tissues, and its effect on overall survival of LUAD patients. CCK-8 assay, Edu assay, and flow cytometry were used to probe the effect of EphrinA3 on the proliferation of LUAD cells, and transwell assay was employed to examine its effect on migration and invasion. In addition, the effect of EphrinA3 on the growth of LUAD was furthe

SUBMITTER: Yiminniyaze R 

PROVIDER: S-EPMC9883548 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature