Genetic variants in RNA m⁵ C modification genes associated with survival and chemotherapy efficacy of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is one of the most common malignant digestive tract tumors with a poor prognosis. RNA 5-methylcytosine (m⁵ C) is an important posttranscriptional widespread modification involved in many biological processes. However, the association between genetic variations of m⁵ C modification genes and the prognostic value of colorectal cancer remains unclear.

Methods

We investigated the association between candidate single nucleotide polymorphisms (SNPs) in 13 m⁵ C modification genes and colorectal cancer overall survival (OS) after chemotherapy by the Cox regression model. The combined effect of selected SNPs on OS, progression-free survival (PFS), and disease control rate (DCR) was assessed by the number of risk alleles (N

SUBMITTER: Chen S 

PROVIDER: S-EPMC9883553 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature